Curcumin is a natural compound found in turmeric, it has a variety of healthy properties including support to the antioxidant system and healthy stress response. Curcumin plays a role in methylation biochemistry by modulating the activity of enzymes involved in methylation reactions.
Curcumin has been found to inhibit the activity of enzymes that catalyze the methylation and demethylation of DNA, such as DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), which can affect the expression of genes.
Curcumin has also been found to interact with the methylation cycle by inhibiting the enzyme methionine synthase (MS) which is responsible for the conversion of homocysteine to methionine, and thus it can affect the availability of methyl groups for methylation reactions.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879467/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163664/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997693/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
