Resveratrol is a polyphenolic compound found in a variety of fruits and vegetables, particularly in grapes and red wine. It plays a role in methylation biochemistry by acting as an support to the antioxidant system and a modulator of the activity of enzymes involved in methylation reactions.
Resveratrol has been shown to have an inhibitory effect on the activity of enzymes that catalyze the methylation and demethylation of DNA, such as DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), which can affect the expression of genes.
Resveratrol has also been found to interact with the methylation cycle by inhibiting the enzyme methionine synthase (MS) which is responsible for the conversion of homocysteine to methionine, and thus it can affect the availability of methyl groups for methylation reactions.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879467/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163664/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997693/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
